Several formulation developments were conducted through a spray drying process to maximize the solubility and chemical stability of Curcumin utilizing Amorphous Solid Dispersion (ASC) process. Two cellulose derivative polymers (Hydroxypropylmethylcellulose acetate succinate/HPMCAS and Polyvinylpyrrolidone/PVP) were utilized to enhance the Curcumin's solubility.
We found that either Curcumin-HPMCAS or Curcumin-PVP could form spray-dried ASDs, and both Curcumin solubility and dissolution rate were much greater than those from pure curcumin.
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