NextHerbal Labs, LLC

Leading Herbal Supplements with Advanced
Formulation Techniques

At a Glance

NextHerbal Labs ("NHL") is a research-driven company located in Colorado, USA, has legacy experience in herbal nutraceutical formulations. NHL has developed and out-licenses its disruptive and cost-effective CannAquaSol technology that promotes healthier administration methods, lower overall dosing and higher effectiveness of ingestible phytocannabinoids.

Nutraceuticals - Where food and pharmaceuticals converge.

Research & Development
NHL has a state-of-the-art R&D laboratory to help the clients formulate innovative products and identify trends early. Our talented and knowledgeable staffs consist of Chemists and Pharmaceutical Scientists.
Many new chemical entities (NCEs) as well as phytochemicals such as phytocannabinoids and curcumin are poorly water soluble, resulting in the low bioavailability. Therefore, solubility enhancement is the number one challenge in formulation development today. One of the main approaches to increase the solubility is Amorphous Solid Dispersion (ASD). ASDs can be created by different techniques such as spray drying, spray congealing and hot melt extrusion. After processing, the bioactive would be dispersed molecularly in a polymeric matrix. We used the ASD technique to enhance the curcumin's solubility. Another technology is Liquisolid technology. This technology was utilized to increase the phytocannabinoids' solubilities.
Some of our nutraceutical delivery systems and formulations were listed as the following:

Water-soluble CBD- and THC-based powders
Water-soluble CBD- and THC-based pellets
CBD- and THC-based sublingual tablets
CBD- and THC-based tableted chewing gums
Orally disintegrating tablets (ODT) infused with CBD and THC
Water-soluble curcumin powder
Enhanced gastric stability of Saffron

CBD: Cannabidiol, THC: Δ9-Tetrahydrocannabinol

Our Formulation and Analytical development team has been provided with a laboratory equipped with all the necessary instruments.
This includes the:
- Balance
- Halogen Moisture Analyzer
- Sieves and sifters
- UV/Visible Spectrophotometer
- Fluid Bed Dryer
- Fluid Bed Processor/Coater (Bottom and Top Spray)
- Spray Dryer
- R&D Single-Punch Tablet Press
- Tablet Coating Machine
- Heidolph SilentCrusher M (High Shear Homogenizer)
- High Performance Liquid Chromatography (HPLC) with UV Detector
- Dissolution Tester: USP Apparatus #1 (Basket) and #2 (Paddle)
- Tablet Hardness Tester
- Rotary Evaporator (Rotavap)

Benefits of Scientific Formulation:
• Combines bioactive agents with excipients to improve chemical solubility, stability and taste
• Improves bioavailability, meaning more bioactive is absorbed into the bloodstream at lower doses
• Produces well-characterized products that are accurate, consistent and reproducible.

At NHL, all formulation developments are supported by comprehensive analytical methods including HPLC assay, impurities profile, dissolution testing, particle size analysis, and others.