CANNAQUASOL™
A Versatile Solution to Improve
Absorption And Efficacy of
Cannabinoids
CannAquaSol™ 1st Generation (Liquisolid Technology)
This patent-pending* 1st generation technology was developed to maximize the solubility, bioavailability and chemical stability of phytocannabinoids.
- Complexation with Cyclodextrins - Nanotechnology/Nanoparticle delivery system. *: US patent pending: "Solid formulations with improved solubility of cannabinoids and preparation method thereof" |
Slide1: Two processes for making the Liquisolid Powders.
Slide2: The Liquisolid formulation, followed by pelletization for making the Liquisolid Pellets [5]. |
Sprinkle dosage form
[7]: H.S. Lee, et al., Sprinkle Formulations - A Review of Commercially Available Products, Asian Journal of Pharmaceutical Sciences (2019), doi: https://doi.org/10.1016/j.ajps.2019.05.003 |
General administration methods for the sprinkle drug products in various dosage forms [7].
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Sublingual CBD/THC Microdosing – The New Frontier of Cannabis Administration
Sublingual Route: Fast & accurate uptake without the hazards of smoking In addition to CannAquaSol powder and pellet, we formulated the Sublingual tablet having the CannAquaSol powder to enhance accurate dosage and immediate effects. This administration involves placing a sublingual tablet under the tongue, allowing the phytocannabinoid(s) to dissolve and enter the bloodstream through the vessel-rich tissues within the sublingual cavity. The onset of pharmacological effects is rapid, and the duration of effects is equivalent to or exceeding other forms of administration. Since the "First Pass Metabolism" (metabolism in the liver) is by-passing with sublingual use, the bioavailability of phytocannabinoid(s) is significantly improved compared to other routes of administration. |
Compressed (Tableted) Chewing Gum
At NextHerbal Labs, a number of CBD- and THC-based chewing gums have been formulated. We used a directly compressible powder which made up of a gum base and sweeteners besides CBD or THC for making the tableted chewing gums. This formulation process does not require high temperature like the traditional chewing gums made by extrusion. Therefore, the process is quick and cost-effective as it adapts to direct compression with standard tableting equipment. Some of the advantages of a chewing gum are:
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Orally Disintegrating Tablet (ODT) Infused with CBD/THC
NextHerbal Labs has developed "Orally Disintegrating Tablets" of two phytocannabinoids. These tablets disintegrate rapidly in the mouth without chewing or water and are formulated for anyone who dislikes swallowing conventional tablet or capsule. Most formulations disintegrate in 30-90 seconds. Benefits of ODT for consumers:
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